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The Polyproxin™ platform

Protein homeostasis or ‘proteostasis’- the maintenance of protein levels and thereby functions - requires a highly complex and dynamic network of interconnected processes tightly regulated by a series of quality control mechanisms and machinery that influence the fate of a protein from synthesis to degradation. 

The common underpinning basis of this network is molecular recognition involving the specific interactions of proteins with each other. The Polyproxin™ platform exploits our deep understanding of these protein-protein interactions to harness proteostasis networks and thereby manipulate protein stability and disease outcome.

The Polyproxin™ platform comprises:

  • Libraries of target-engagement modules, degradation-inducing modules, and connecting modules

  • A mix-and-match format to identify the combination of modules that elicits the most effective knockdown of target protein.
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The platform can be directed to diverse targets and disease states using the following approach:

  • Combining principles of protein engineering with a deep understanding of proteostasis networks and machineries
  • Mining of protein-structure and protein-interaction databases
  • Informatics-driven selection of disease targets and pathways
  • A holistic strategy to enable access to the broadest range of degradation pathways including, but not limited to, the ubiquitin-proteasome system.
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